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Burke Neurological Institute (BNI)


As we start a new year, we want to make 2021 the year that we share the great news on the world-class research that our member institutions, like yours, are doing right now. The work that our members are doing is crucial and can have a significant impact to our world.
Recently, the Burke Neurological Institute (BNI) was featured in the news on CNN, “New Data Suggests Raising Vitamin B1 Levels very high Helps People Living with mild Alzheimer’s Disease”. The story mentioned that Dr. Gary E. Gibson’s laboratory at the Burke Neurological Institute did an exploratory clinical trial with physicians at the Burke Rehabilitation Hospital, and suggests that Benfotiamine is safe and potentially efficacious in improving cognitive outcomes among people living with Mild Cognitive Impairment and mild Alzheimer’s disease (AD). The article goes on to say that Benfotiamine, a therapeutic drug that raises blood vitamin B1 (thiamine) levels very high, has been tested as a twelve-month treatment. High vitamin B1 has many benefits including raising brain glucose utilization. The results are now published in a manuscript online by the Journal of Alzheimer's Disease.
This study is important because every 65 seconds, someone in the United States is given the devastating diagnosis of Alzheimer’s disease (AD). With a progressively aging population, current forecasts predict the prevalence of Alzheimer’s disease will inflate from more than five million to a projected 14 million Americans by 2050(1). While the human brain represents only two percent of the body weight, it utilizes around 20 percent of total body glucose. Research findings show that individuals living with AD may have decrease in glucose utilization 20-30 years prior to signs of memory loss. The hope is that by increasing glucose utilization, it will ultimately slow or stop memory decline.
This clinical trial was supported by the National Institutes of Health (NIH) and the Alzheimer’s Drug Discovery Foundation.  Thanks to Christine Hughes, Vice President of Institutional Advancement from BNI for sharing this great news.
Help make 2021 a positive year by sharing your story! We’d like to include your great news with the membership in a future AIRI Member Minute. Just email me your information, press release, links, or photos.
Here’s to a great 2021! Thank you for your membership in AIRI, and for all the great work that your institution does for the good of our world.
David Issing
Executive Director
AIRI Management Office